Tessa Therapeutics is committed to improving the lives of cancer patients worldwide. Through the development of next-generation cell therapies, we seek to provide patients with more effective and longer-lasting treatment options for a broad range of cancers.

T Cell Therapy Treatment: How Does it Work?

Target Indications

Our goal is to develop safe and effective cell therapies to transform the lives of patients with cancer. To learn more about available clinical trials, visit and search by company, disease or medicine.

Epstein-Barr Virus (EBV)-associated lymphomas

Malignant lymphomas are malignancies arising from lymphoid organs and tissues. Approximately 589,580 new cases of lymphoma were diagnosed worldwide with mortality of 274,891 in 20181. Oncogenic EBV is associated with various types of lymphoma, including post-transplant lymphoproliferative disease (PTLD),  Hodgkin lymphoma (HL), Non-Hodgkin lymphoma (NHL) and NK/T cell lymphoma2. Standard treatments of advanced HL and NHL are chemotherapy, radiotherapy and targeted therapy, and recently, CAR-T cell therapy was approved for a type of NHL. PTLD currently has limited treatment options with anti-CD20 antibody as the standard treatment.

1. Globocan 2018,
2. Malignancies associated with epstein-barr virus: pathobiology, clinical features, and evolving treatments. Neparidze N, Lacy J,  Clin Adv Hematol Oncol. 2014 Jun;12(6):358-71.

CD30-positive Hodgkin lymphoma

CD30 is universally expressed in classical Hodgkin Lymphoma (cHL). Patients with relapsed or refractory cHL have limited treatment options and poor outcomes despite recently approved immune-checkpoint inhibitors indicated for patients who have relapsed after 3 or more lines of therapy.

CD30-positive lymphomas

CD30 is expressed in certain hematologic malignancies, including Hodgkin lymphoma and certain non-Hodgkin lymphomas (anaplastic large cell lymphoma, diffuse large B-cell lymphoma etc. The variable expression of CD30 on both normal and malignant lymphoid cells has resulted in research confirming it as a validated drug target for various hematologic malignancies.

HER2-positive Solid Tumors

Human Epidermal Growth Factor Receptor 2 (HER2) is over expressed in multiple solid tumors, including breast, bladder, lung, colorectal, gastric, and head and neck cancers. The overexpression of HER2 is an indicator of poor prognosis, increased recurrence and decreased overall survival (OS).

Expanded Access

Tessa Therapeutics is dedicated to the development of next-generation cell therapies for a variety of hematologic malignancies and solid tumors.

At this stage of our drug development program for investigational product CD30-directed genetically modified autologous T cells (CD30.CAR-T), we are evaluating the safety and efficacy of our proprietary process of isolating human T cells from peripheral blood mononuclear cells for infusion into patients with resistant Hodgkin lymphoma. This research is being conducted through clinical trials that—with continued success—may provide the basis for a submission to the U.S. Food and Drug Administration (FDA) for drug approval.

To learn more about our clinical trials, including eligibility requirements for participating in ongoing studies, please visit, a U.S. government-run database listing private and publicly funded clinical studies conducted around the world.

As part of the drug development process, the FDA allows for Expanded Access or Compassionate Use of investigational drugs prior to regulatory approval.  At this time, Tessa Therapeutics does not have a compassionate use program. As cell therapy is a specialized process, we prefer that Hodgkin lymphoma patients consult with a nearest clinical site—since these physicians and facilities are most able to deliver the complex treatment and monitoring required.

For any additional questions, please contact us at