Patients

T Cell Therapy Treatment: How Does it Work?

Step 1: Blood Collection

Patient’s blood is collected at hospital site.

Step 2: Transportation & Handling

Collected blood is transported to Tessa’s central production facility or satellite labs.

Step 3: VST Initiation & Expansion

Patient’s white blood cells are isolated and the virus-specific T (VST) cell population are selectively activated & expanded.

Step 4: Preconditioning Chemotherapy

Coinciding with the VST production period, the patient receives preconditioning chemotherapy.

Step 5: Infusion & Monitoring

Tessa ships the patient’s VSTs to the hospital site, where the investigational therapy is infused in the patient & is carefully monitored for any adverse reactions.

Indications we Target

Nasopharyngeal Cancer

Nasopharyngeal cancer (NPC) originates in the nasopharynx, an area at the upper part of the throat behind the nose. Approximately 92,5001 new cases of NPC are diagnosed worldwide each year with mortality of close to 55,0001. Although radiotherapy is the main avenue of treatment for early-stage NPC, 20-30% of patients are diagnosed at an advanced stage of disease and are not considered curable. NPC is strongly associated with Epstein-Barr Virus (EBV) infection, particularly in Asia, where close to 100% of NPC tumors are EBV-positive.

Cervical Cancer

Cervical cancer (CC) is a cancer that originates in the cervical tissue of the female reproductive tract. Approximately 560,0001 new cases of CC are diagnosed worldwide each year with mortality of close to 300,0001. Human papillomavirus (HPV) infection is strongly associated with CC and 70 – 80% of CC are HPV-positive. Surgery, chemotherapy and/or radiotherapy are often used to treat advanced CC. Although several HPV vaccines are available, these vaccines cannot treat CC patients who are already infected with HPV.

Oropharyngeal Cancer

Oropharyngeal cancer (OPC) is a cancer that originates in the oropharynx, an area at the back of the mouth that connects to the esophagus. Approximately 154,0001 new cases of OPC are diagnosed worldwide each year with mortality of close to 100,0001. 70% of these cancers are HPV-positive. Surgery, chemotherapy and/or radiotherapy may be used to treat OPC. As with CC, vaccines against HPV are unable to treat OPC patients who are already infected with the virus.

Head and Neck Cancer

Head and neck cancer encompasses a group of similar cancers originating from tissues of the lip, mouth, nose, sinuses, pharynx and larynx.  500,000 – 600,0001 new cases of HNC are diagnosed worldwide each year. Treatment depends on the type and location of the cancer, although surgery followed by chemotherapy and/or radiotherapy are frequently indicated.

1 World Health Organization: GLOBOCAN 2012 Estimated Cancer Incidence, Mortality, and Prevalence Worldwide in 2015.