T Cell Therapy Treatment: How Does it Work?
Indications we Target
Nasopharyngeal cancer (NPC) originates in the nasopharynx, an area at the upper part of the throat behind the nose. Approximately 92,5001 new cases of NPC are diagnosed worldwide each year with mortality of close to 55,0001. Although radiotherapy is the main avenue of treatment for early-stage NPC, 20-30% of patients are diagnosed at an advanced stage of disease and are not considered curable. NPC is strongly associated with Epstein-Barr Virus (EBV) infection, particularly in Asia, where close to 100% of NPC tumors are EBV-positive.
Cervical cancer (CC) is a cancer that originates in the cervical tissue of the female reproductive tract. Approximately 560,0001 new cases of CC are diagnosed worldwide each year with mortality of close to 300,0001. Human papillomavirus (HPV) infection is strongly associated with CC and 70 – 80% of CC are HPV-positive. Surgery, chemotherapy and/or radiotherapy are often used to treat advanced CC. Although several HPV vaccines are available, these vaccines cannot treat CC patients who are already infected with HPV.
Oropharyngeal cancer (OPC) is a cancer that originates in the oropharynx, an area at the back of the mouth that connects to the esophagus. Approximately 154,0001 new cases of OPC are diagnosed worldwide each year with mortality of close to 100,0001. 70% of these cancers are HPV-positive. Surgery, chemotherapy and/or radiotherapy may be used to treat OPC. As with CC, vaccines against HPV are unable to treat OPC patients who are already infected with the virus.
Head and Neck Cancer
Head and neck cancer encompasses a group of similar cancers originating from tissues of the lip, mouth, nose, sinuses, pharynx and larynx. 500,000 – 600,0001 new cases of HNC are diagnosed worldwide each year. Treatment depends on the type and location of the cancer, although surgery followed by chemotherapy and/or radiotherapy are frequently indicated.
1 World Health Organization: GLOBOCAN 2012 Estimated Cancer Incidence, Mortality, and Prevalence Worldwide in 2015.