Our robust clinical pipeline of autologous and allogeneic cell therapies targets a variety of hematologic malignancies and solid tumors.
TT12, TT16 and TT11x are Investigator-initiated trials sponsored by Tessa. All of Tessa’s programmes are not yet being offered for sale and are currently undergoing investigation. Accordingly, Tessa makes no claim as to their safety and effectiveness for the purposes for which they are under investigation.
Epstein-Barr Virus-Specific T Cells (EBVSTs) for Nasopharyngeal Cancer (NPC)
Using our proprietary Virus-Specific T cell (VST) platform, we are able to target specific Epstein-Barr Virus (EBV) proteins that are present on EBV-positive tumors.
Our EBVSTs extracted from a patient’s blood are enhanced for anti-tumor potency, selectively activated and expanded ex vivo before infusion back into the patient.
A Phase III Trial Evaluating Chemotherapy and Immunotherapy for Advanced Nasopharyngeal Carcinoma (NPC) Patients
Indication: Nasopharyngeal cancer (NPC)
US FDA Orphan Drug and Fast Track Designation
Trial Number: NCT02578641
A Multicentre, Randomized, Open-Label, Phase III Clinical Trial of Gemcitabine and Carboplatin Followed by Epstein-Barr Virus-Specific Autologous Cytotoxic T Lymphocytes Versus Gemcitabine and Carboplatin as First Line Treatment for Advanced Nasopharyngeal cancer Patients.
- California, United States
- Massachusetts, United States
- Texas, United States
CD30-Directed Genetically Modified Autologous T cells (CD30.CAR-T) in Adult and Pediatric Patients with Relapsed or Refractory CD30 Positive Classical Hodgkin Lymphoma
Tessa is initiating a pivotal Phase II clinical study to investigate an autologous CD30.CAR-T cell therapy program targeting relapsed or refractory classical Hodgkin Lymphoma. CD30-targeting CAR enables the recognition and elimination of CD30-positive lymphoma cells.
This therapy is developed based on encouraging clinical data from two independent CD30.CAR-T Phase I/II studies conducted by Baylor College of Medicine (Trial Number: NCT02917083), and the University of North Carolina (Trial Number: NCT02690545), for patients with relapsed or refractory CD30-positive Hodgkin Lymphoma. CD30.CAR-T were administered after lymphodepletion with either bendamustine alone, bendamustine and fludarabine, or cyclophosphamide and fludarabine.
Allogeneic CD30-Chimeric Antigen Receptor (CAR) Epstein-Bar Virus-Specific T cells (EBVSTs) for CD30-Positive Lymphomas
Tessa is developing a next-generation, allogeneic VST therapy targeting CD30-Positive Lymphomas. EBVST cell lines derived from healthy donors are modified with a CD30 Chimeric Antigen Receptor (CAR) and matched to suitable patients to target CD30+ cancer cells within their bodies.
This therapy is developed based on an ongoing Phase 1 clinical study (Trial Number: NCT02287311) conducted by Baylor College of Medicine, which investigates the feasibility and safety of allogeneic EBVSTs in EBV-associated lymphomas.
Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL) (MABEL)
Indication: EBV-associated lymphomas and PTLD
Trial Number: NCT02287311
Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL)
Texas, United States
Human Papillomavirus-Specific T Cells (HPVSTs) for HPV-Associated Cancers
Tessa’s TT12 is an autologous T cell therapy product composed of HPVSTs that have been trained to target HPV 16/18 antigens and genetically modified with a decoy TGF-β receptor to overcome the immuno-suppressive tumor microenvironment.The safety and optimal dose selection of armored HPVSTs in combination with an anti-PD-1 antibody is currently being evaluated in an ongoing investigator-sponsored Phase 1 trial (NTC02379520) in the United States, in patients with relapsed/resistant HPV-associated cancers.
In collaboration with MSD (tradename of Merck & Co., Inc., Kenilworth, N.J., USA), Tessa will conduct a separate, multi-center Phase 1b/2 trial to evaluate the safety and efficacy of our autologous HPVST therapy in combination with MSD’s anti-programmed death receptor-1 (PD-1) antibody, Pembrolizumab (KEYTRUDA®), following pre-conditioning lymphodepletion chemotherapy, in patients with recurrent/refractory or metastatic HPV 16/18-positive cervical cancer. More details here.
Overview of HPVST therapy
HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA (HESTIA)
Indication: HPV-associated cancers
including oropharyngeal cancer, cervical cancer, anal cancer, vulvar cancer and penile cancer
HER2 CAR-Ts + Oncolytic & Helper-Dependent Adenovirus for HER2-positive solid tumors
Human Epidermal Growth Factor Receptor 2 (HER2) is over expressed in multiple solid tumors, including breast cancer, bladder cancer, lung, colorectal, gastric carcinoma, and head and neck. The overexpression of HER2 is an indicator of poor prognosis, increased recurrence and decreased overall survival (OS). The administration of our therapy is a two-step process: the adenoviruses are administered locally into the tumor, followed by infusion of HER2 CAR-Ts.
About HER2-positive cancers
Selectively replicates and kills tumor cells to promote inflammation
Expresses IL-12 and checkpoint inhibitor anti-PD-L1. Modulates the tumor microenvironment to promote a strong anti-tumor response.
HER2-specific CAR-T Cell
Targets and specifically kills HER2 expressing tumor cells